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Automatically identify all apps and dependencies that run in your environment with ThreatLocker Allowlisting. With 16,000+ pre-built applications already recognized, you can quickly build your allowlist and reduce the time spent creating policies. Once you select which applications you want to run, everything else is blocked by default, including ransomware, scripts, and downloads. Even if a user clicks a phishing link or downloads malware, it won’t execute without your permission.
Featured capability: Allowlisting
Get granular control over what applications can access, connect to, and interact with to protect your sensitive data. Every action is logged in the Unified Audit, so you can confidently support HIPAA and HITRUST requirements.
Featured capabilities: Ringfencing™, Privileged Access Management
Restrict how applications behave in the network and prevent threats from spreading. Even if malicious software reaches an application or endpoint, it’s isolated and unable to spread.
Featured capabilities: Zero Trust Endpoint Firewall, Zero Trust Network Access, Zero Trust Cloud Access
Simplify your implementation of a Zero Trust model without disrupting clinician or staff workflows. Approved applications run as expected while you gain centralized control, rapid approval capabilities, and policy-driven security to keep your environment locked down without impacting patient care.
Featured capabilities: Cyber Hero Approvals, Ringfencing™
Before ThreatLocker we faced risks we couldn’t fully control. Now, we’re doing a much better job of creating a secure environment for our patients, doctors, and manufacturing partners.
Tools like ThreatLocker play a critical role in meeting compliance standards by giving us granular control over system access and helping us confidently demonstrate compliance to auditors.
Having a piece of software that prevents any unauthorized application from running seemed like the best solution one could ask for.
ThreatLocker helps immensely—they have our backs 24/7. They're often 30 minutes to an hour ahead of other security vendors we use when they reach out about potential issues. That's what helps me: knowing people are watching, and that we're not alone in this.


Two hospitals faced the same ransomware attack. At one hospital, attackers successfully encrypted critical systems, forcing staff to work through outages and disrupting patient care.
At the other, ThreatLocker blocked the unauthorized encryption attempt before it could execute. Unable to encrypt systems or shut down operations, the attackers lost their leverage and moved on, while clinicians continued caring for patients.
